SARS-CoV-2 seroconversion during the postoperative period in pediatric patients

Principal Investigators

Objectives

Undergoing surgery may increase a person's susceptibility to COVID-19 as well as accelerating and exacerbating its evolution. However, the available data is not conclusive and the available studies are only based on adults. Thus, this project aims at determining the seroconversion rate in the pediatric population undergoing surgery, with the following specific objectives:

- To show the clinical and seroconversion differences to the adult population.

- To elucidate whether there are changes in the postoperative clinical course of the pediatric population depending on whether they develop COVID-19 infection after the surgical procedure.

Project design

Observational prospective cohort study of patients who undergo surgery at SDJ Barcelona Children's Hospital.

Cohorts

Patients (0-18 years old, n = 1000) undergoing surgery in SJD Barcelona Children's hospital who have had a negative PCR for SARS-CoV-2 48 hours before surgery. Patients who have undergone another surgery in the month before the study will be excluded.

Based on the seropositive conversion rate in the general population at the time of the study (1.5%), we expect to obtain about 15 patients who become positive after surgery from a sample of 1000 patients. However, the seroconversion rate in children is unknown and may be lower than that of the general population.

Samples

We will take the following samples from all patients in the study:

  • Nasal swabs: PCR to detect SARS-CoV-2 48 hours before surgery.
  • Blood samples:
    • Rapid test for the detection of IgG/IgM antibodies against SARS-CoV-2 during surgery.
    • Detection of IgG/IgM antibodies against SARS-CoV-2 4 weeks after surgery.

The morbidity and mortality rate between the group of patients who test positive for SARS-CoV-2 and those who do not will be compared.

Group members