COVID19 and pregnancy: social online survey to assess clinical spectrum and impact on maternal-fetal wellbeing
What is the impact of COVID-19 in mothers and fetuses? We do not have an answer to this question.
- Despite most pregnancies with COVID-19 have a mild disease, there are reports of cases with severe or even fatal presentations, which create alarm among women, doctors and the society.
- Likewise, pregnant women are highly vulnerable to the "collateral damage" of COVID-19, i.e. the long term social, wellbeing and economic consequences.
- Because they are young, and apparently "more protected" from COVID-19, there has been a lack of attention on pregnancy.
- This has led to lack of reliable scientific data, generating stress on women and preventing evidence-based information to inform the society, make recommendations and guide policies.
- Therefore, there is an urgent need to have solid data on how COVID19 affects pregnancy and their child.
- International collaboration is critical need to accelerate generation of knowledge.
What are our main questions
How is COVID-19 presenting in pregnant women?
Is it worse in pregnancy like influenza? Could we predict which women are at increased risk?
What is the impact on pregnancy outcomes?
Does it increase the risk of miscarriage, prematurity or fetal death?
- How is the pandemics affecting mental well-being in pregnant women and their children?
- Do lifestyle, socio-economic and air pollution play a role in COVID-19 in pregnancy?
- Will the children of the "Covid generation" develop well?
To provide answers to these critical questions we have designed AN AMBITIOUS RESEARCH PROGRAMME with several lines and studies to create different cohorts.
Registries of symptomatic COVID-19 cases in pregnancy are extremely valuable to describe the disease, but normally detect the most severe cases. It is critical to do prevalence studies, i.e. study consecutive patients with and without COVID-19, to capture the asymptomatic and mild forms of COVID-19 and understand the real impact
This is an ambitious study for all pregnant women, with and without COVID-19. A short and realistic survey using a structured questionnaire that can be filled in just 5-10'. Despite the short time it takes, it will provide extremely valuable information about the presentation of the disease, the course of pregnancy and the level of anxiety by means of validated questionnaires. We will use geolocation, and available large databases on socio-economic and air pollution maps to model these factors by means of artificial intelligence approaches.
We have developed a web survey in 8 languages and our collaborators are translating this survey into other languages.
We expect to collect responses for 100,000 women. This will allow developing unique studies that by means of artificial intelligence will provide answers to critical public health questions for COVID-19: which are the socio-economic determinants or the influence of environment and pollution? Does COVID increase maternal stress, and does increased maternal stress increase the susceptibility to COVID-19?
We expect to complete this study by the end of June.
- To describe the prevalence of SARS-CoV-2 infection in pregnant women in different countries and regions of the world.
- To describe the clinical spectrum and the impact on perinatal outcomes at different moments of gestation.
- To evaluate geographical or health system factors associated with the clinical presentation and the rate of severe complications.
- To evaluate factors associated with infection and clinical presentation, including stress.
Data and samples
We obtain structured clinical information about the pregnancy, symptoms of COVID-19, clinical history, perinatal and maternal outcomes. The survey results will be analyzed in collaboration with B2Slab - BarcelonaTech - UPC.
A network of excellence. International institutions
- Sant Joan De Déu Children's Hospital (SJD), Spain: Francesca Crovetto, Elisenda Bonet-Carne, Begonya Nafria, Alexandre Perera.
- Hospital Clinic Barcelona (HCB), Spain: Fàtima Crispi.
- Hospital Sant Pau Barcelona, Spain: Elisa Llurba, Mónica Cruz Lemini.
- Hospital Italiano de Buenos Aires, Argentina: Lucas Otanño
- Hospital Universitario de Chile, Chile: Mauro Parra Cordero
- ESE Clinica Maternidad Rafael Calvo, Colombia: Jezid Miranda
- Żelazna Medical Center, Poland: Anna Kajdy
- Institute of Clinical Sciences Lund, Sweden: Stefan Hansson
The network is still increasing. Information will be updated soon.